A new era in healthcare for nursing dale halsey lea, mph, rn, cgc, faan consultant, public. If you continue browsing the site, you agree to the use of cookies on this website. Genetic factors and aging seem to account for most of these variations. Metformin is the undisputed queen among type 2 diabetes drugs. Advances in pharmacogenetics have been enabled by highthroughput technology that allows for the screening of tens of thousands of genes rapidly and simultaneously. Pharmacogenetics is the study of variations in dna sequence related to drug response. Pharmacogenetics for safe codeine use in sickle cell.
Dec, 2017 download ppt at baseline, ssris were the most prescribed treatment regimen 43. By forest tennant, md, drph 1 and brian hocum, pharmd, cgp 2. Pharmacogeneticsbased strategy for codeine prescribing. Pharmacogenetics of propofol and depth of anesthesia. Major depressive disorder mdd and generalized anxiety disorder gad are associated with significant morbiditymortality risk. Encepp plenary meeting introduction to pharmacogenomics marisa papaluca. Current management is inadequate as half of individuals do not respond to firstline therapies. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Genomic medicine, which uses dna variation to individualise and improve human health, is the subject of this series of papers. Moreover, the evolution of biotechnology and the sequencing of human dna have allowed the creation of pharmacogenomics, a branch of genetics that analyzes human genes, the rnas and proteins encoded by them, and the interand intraindividual variations in expression and function in relation to drug response.
The activity of drugmetabolizing enzymes often varies widely among healthy people, making metabolism highly variable. Food and drug administration fda approved a new label for clopidogrel with the addition of a boxed warning regarding pharmacogenetics, noting diminished effectiveness of therapy in. Pharmacogenetics seeks to contribute through geneticguided drug and dose selection strategies. Pharmacogenetics pgx is the study of how genetic variation changes an individuals response to a medication a single nucleotide polymorphism snp is the most common type of genetic variation if a snp affects the function of a gene that codes for a drug metabolizing enzyme or a drug transporter or a drug. Combines pharmacology and genomics develops an effective and safe medication plan specific to each patients dna all drugs are taken through several biochemical pathways to be broken down after a patient takes them. For example, the dna chip is a microchip that uses hybridization technology to concurrently detect the presence of tens of thousands of sequences in a small sample.
An introduction to pharmacogenomics ashim malhotra p glycoprotein, 111 clinical implications of pharmacogenomics, 111 adverse drug reactions warfarin pharmacogenetic testing prior to prescribing summary, 1 a dvances in health care have led to a significant improvement in patient survival in the past three decades. Specifically, the only ongoing project in europe since the 1st of january of 2016 is ubiquitous pharmacogenomics upgx. Pharmacogenetics in psychiatric disorders idaho health care. Office 365 plans include premium versions of these applications plus other services that are enabled over the internet, including online storage with onedrive and skype minutes for home use. Heart disease remains the leading cause of death in the united states us, accounting for approximately 610,000 deaths annually.
It is often associated with microsoft and is commonly used for school and work presentations. Clinical pharmacogenetics implementation consortium guidelines for dihydropyrimidine dehydrogenase genotype and. Warfarin, paclitaxel, morphine, statins, acetaminophen. Of concern, only 54 % of hypertensive adults in the us have their blood. Pharmacogenetics and pharmacogenomics is an emerging science that has a great application in drug development and therapeutics. Dec 10, 2009 propofol, 2,6diisopropylphenol is a shortacting anesthetic drug used for induction and maintenance of anesthesia. Pharmacogenetics and pharmacogenomics slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. This type of presymptomatic diagnosis can to a great extent prevent cancer mortality by adopting frequent screening for the suspected cancer risk and catching it at the very early stage. Pharmacogenetics of propofol and depth of anesthesia full. Propofol, 2,6diisopropylphenol is a shortacting anesthetic drug used for induction and maintenance of anesthesia. During this time, a few cytochrome p450 cyp450 enzymes have been identified as being particularly important to the metabolism of certain pharmaceutical agents commonly used in pain treatment, such as opioids, antidepressants, and antiinflammatory agents. Telechargez microsoft powerpoint 20 microsoft office.
Lamba, in innovative approaches in drug discovery, 2017. Pharmacogenetics and pharmacogenomics are often used interchangeably but do have distinct meanings. Pharmacogenetics and pharmacogenomics in moderatetosevere. She is enthroned atop all professional society algorithms as the firstline drug to be prescribed as soon as the diagnosis is made 1,2,3, in the absence of contraindications such as severe renal or hepatic insufficiency. Probably the ultimate proof to support the introduction of pharmacogenetics in the clinical practice will derive from the several ongoing implementation projects in europe and in the us. There are two major sets of guidelines regarding warfarin pharmacogenetics, although both were published prior to publication of the most recent randomized controlled trials. Pharmacogenetics of remifentanil in patients with hypertension undergoing cesarean delivery under general anesthesia the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Our goal is introduction of pharmacogenetic testing to healthcare systemof kazakhstan health centers, hospitals. Clinical pharmacogenetics implementation consortium guidelines for cyp2c19 genotype and clopidogrel therapy. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. How i tricked my brain to like doing hard things dopamine detox duration. Our pharmacogenetics based codeine prescribing strategy is consistent with both the fda boxed warning for codeinecontaining products and the cpic guideline for cyp2d6codeine.
The goals of pharmacogenetics are to optimize drug efficacy and limit drug toxicity based on an individuals dna. The majority of cyp2c9 variants impacting warfarin dosing are nonsynonymous single nucleotide polymorphisms snps that occur in the exonic regions of the gene and lead to reduced enzyme activity against swarfarin and consequently lower warfarin dose requirements. Clinical pharmacogenetics, the use of genetic data to guide drug therapy decisions, is beginning to be used for medications commonly prescribed. Design a professional presentation using microsoft powerpoint.
Pharmacogenetics of anticancer monoclonal antibodies. Theyre available as a onetime purchase for use on a single pc. This is because among the 12 available drug classes for type 2 diabetes, it alone. Office 20 include essential applications such as word, excel, powerpoint, and outlook.
Pharmacogenetics for safe codeine use in sickle cell disease. The journal brings together papers from the entire spectrum of biomedical research and science, including biochemistry, bioinformatics. Find powerpoint presentations and slides using the power of, find free presentations research about pharmacogenetics ppt. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Ppt pharmacogenetics and pharmacogenomics powerpoint presentation free to download id. The idea that genetic variation can be used to individualise drug therapythe topic addressed hereis often viewed as within reach for genomic medicine. Aug 11, 2018 benefits of pharmacogenetics are twofold. Pharmacogenomics analyzes how the genetic makeup of an individual affects hisher response to drugs. Despite the increasing scientific understanding of pharmacogenetics, anticipated benefit and patient interest, which may all drive eventual clinical uptake, two major hurdles for physicians and insurers are the absence of robust data and educationknowledge of pharmacogenetics lesko and johnson, 2012. It is important when discussing genetics and pharmacogenetics pgx in clinical pharmacology and drug development to. It deals with the influence of acquired and inherited genetic variation on drug response in patients by.
In this context, drug response concerns therapeutic response and side effects. Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeineprescribed mother. The aim of this study is to evaluate plasma concentrations of propofol in relation to depth of anesthesia, measured by continuous eeg and to correlate plasma concentrations with genetic analyses of liver enzymes responsible for drug. Gene therapy aims to cure disease caused by genetic defects by changing gene expression.
Most people will use powerpoint when they have a speech to deliver or if they are teaching a large group so that they can get their thoughts. Our pharmacogeneticsbased codeine prescribing strategy is consistent with both the fda boxed warning for codeinecontaining products and the cpic guideline for cyp2d6codeine. View and download powerpoint presentations on pharmacogenetics ppt. Pharmacogenetics based strategy for codeine prescribing.
Pharmacogenetics and pharmacogenomics in moderateto. Many drugs are intrinsically unsafe and could be made safer. View 20 genetics, genomics and pharmacogenetics iba 25. Field of pharmacogenetics study of how genes affect an individuals response to drugs. Pharmacogenetics and pharmacogenomics linkedin slideshare.
Concerns about genetic testing for schizophrenia among young adults at clinical high risk for psychosis. Pharmacogenetics involves variations in drug response due to genetic makeup. Role of pharmacogenomics in ppt authorstream presentation. Pharmacogenetics in patient care 60% of drugs causing adr are metabolized by polymorphic enzymes detect polymorphism of genes coding for drug metabolism assists in dosage selection or modification ex. Combines pharmacology and genomics develops an effective and safe medication plan specific to each patients dna all drugs are taken through several biochemical pathways to be broken down after a patient takes them all pharmaceutical companies by law must pronounce the exact biochemical. Thus, pharmacogenetics aims to use genetic information to choose a drug, drug dose, and treatment duration that will have the greatest likelihood of achieving therapeutic outcomes with the least. Pharmacogenetics and pain management clinical use and interpretation of the common pharmacogenetic tests. Pharmacogenetics pgt is a subset of pharmacogenomics pgx and is defined as. Using a pharmacogenomic algorithm to guide the treatmen t of depression. Warfarin pharmacogenetics in guidelines and understanding the place of warfarin pharmacogenetics in therapy after coag and eupact.
Sep 18, 2017 pharmacogenetics is the study of variations in dna sequence related to drug response. Winner of the standing ovation award for best powerpoint templates from presentations magazine. Although either term refers to the use of genetic information to guide therapeutic decisionmaking. Heyderman rs, alfirevic a, pirmohamed m 20 association of human leukocyte antigen. Ppt pharmacogenetics and pharmacogenomics powerpoint. Implications of pharmacogenomics for anesthesia providers. Pdf pharmacogenetics of adverse drug reactions researchgate. Monoclonal antibodies mabs are a rapidly evolving field in cancer therapy, however a number of newly developed and highly effective mabs e.
The use of pharmacogenetics to increase the safety of. The camh pharmacogenetics program is a project to identify genetic variants that influence psychiatric drug response and adverse side effects. The goals of pharmacogenetics are to optimize drug therapy and limit drug toxicity based on an individuals genetic profile. Powerpoint presentations on pharmacogenomics and personalized. The science that allows us to predict a response to drugs based on an individuals genetic makeup felix frueh, associate director of. Clinical utility of pharmacogeneticsguided treatment of. Pharmacogenetics is the study of the impact of genetic polymorphisms on drug response. Prolonged episodes increase impact on quality of life, risk for suicide, and harbor greater societal costs. The aim of this study is to evaluate plasma concentrations of propofol in relation to depth of anesthesia, measured by continuous eeg and to correlate plasma concentrations with genetic analyses of liver enzymes responsible for drug elimination.
New applications of disease genetics and pharmacogenetics to drug. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that. Pharmacogenomics is defined as the study of how drugs interact with the total expression output of the genome, to influence biological pathways and processes. Integration of pharmacogenetics into clinical practice. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. Pharmacogenomics is the study of the role of the genome in drug response. A companion to braunwalds heart disease fourth edition, 20 therapeutic implications in march 2010, the u. Hypertension is an important risk factor for heart disease and affects more than one billion individuals worldwide and one third of the us adult population 2, 3. Pharmacogenetics focuses on the influence of single genes on drug response pharmacogenomics takes a broader view of the influence of an individuals entire genome on.
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